Folic Acid Supplementation Promotes Hypomethylation in Both the Inflamed Colonic Mucosa and Colitis-Associated Dysplasia.

Wen-Chi L ChangJayashri GhoshHarry S CooperLisa VanderveerBryant SchultzYan ZhouKristen N HarveyEsther KaungaKarthik DevarajanYuesheng LiJaroslav Jelinek Mariana F FragosoCarmen SapienzaMargie L Clapper

Published in: Cancers (2023)

High-dose FA created an altered epigenetic field effect within the non-neoplastic colonic mucosa. The observed decrease in site-specific DNA methylation altered oncogenic pathways and promoted colitis-associated CRC.

Keyphrases

dna methylation
ulcerative colitis
high dose
gene expression
genome wide
low dose
stem cell transplantation
transcription factor
copy number