MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis.
Parvez KhanJawed Akhtar SiddiquiPrakash G KshirsagarRamakanth Chirravuri VenkataShailendra Kumar MauryaTamara MirzapoiazovaNaveenkumar PerumalSanjib ChaudharyRanjana Kumari KanchanMahek FatimaMd Arafat KhanAsad Ur RehmanImayavaramban LakshmananSidharth MahapatraGeoffrey A TalmonPrakash KulkarniApar K GantiManeesh JainRavi SalgiaSurinder Kumar BatraMohd Wasim NasserPublished in: Molecular cancer (2023)
Our findings revealed that miR-1 is a critical regulator for decreasing SCLC growth and metastasis. It targets the CXCR4/FOXM1/RRM2 axis and has a high potential for the development of novel SCLC therapies. MicroRNA-1 (miR-1) downregulation in the tumor tissues and serum samples of SCLC patients is an important hallmark of tumor growth and metastasis. The introduction of miR-1 in SCLC cell lines decreases cell growth and metastasis. Mechanistically, miR-1 directly targets CXCR4, which further prevents FOXM1 binding to the RRM2 promoter and decreases SCLC growth and metastasis.