A localized pallidal physiomarker in cervical dystonia.

Wolf-Julian Neumann Christos GanosSiobhan EwertJulius HueblChristof BrückeColleen SlentzGerd-Helge SchneiderAndrea A Kühn

Published in: Annals of neurology (2017)

Our findings suggest that theta oscillations in the internal pallidum are robustly associated with dystonic symptoms in cervical dystonia and may be a useful biomarker for adaptive closed-loop stimulation. Furthermore, theta oscillatory activity may have a predictive value for the clinical benefit after chronic DBS that could be used to improve intraoperative neurophysiological target mapping during electrode implantation. Ann Neurol 2017;82:912-924.

Keyphrases

deep brain stimulation
working memory
transcranial magnetic stimulation
high frequency
prefrontal cortex
high resolution
early onset
patients undergoing
neural network
physical activity
high density
sleep quality
carbon nanotubes
depressive symptoms
mass spectrometry