[Effect of Xiongcan Yishen Formula on ferroptosis in mouse TM3 Leydig cells after oxidative stress injury].

A-Jian PengGang NingHui WuBo-Nan LiRuo-Bing ShiHao-Yu WangWei LiuXue TangXing Zhou

Published in: Zhonghua nan ke xue = National journal of andrology (2024)

Following H2O2 exposure, oxidative stress can induce ferroptosis in mouse TM3 Leydig cells. XYF can antagonize OSI and ferroptosis in TM3 cells by activating the SLC7A11/GSH/GPX4 axis, which may underlie the mechanism of XYF in the treatment of male late-onset hypogonadism.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
late onset
cell death
endoplasmic reticulum stress
signaling pathway
dna damage
early onset