Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline.

Samuel AsanadMichele FantiniWilliam SultanMarco NassisiChristian M FelixJessica WuRustum KaranjiaFred N Ross-CisnerosAbhay P SagareBerislav V ZlokovicHelena C ChuiJanice M PogodaXianghong ArakakiAlfred N FontehAlfredo A SadunMichael G Harrington

Published in: PloS one (2020)

Our retinal data predict which individuals have CSF biomarkers of AD pathology before cognitive deficits are detectable with 87% sensitivity. Such results from easy-to-acquire, objective and non-invasive measurements of the RNFL merit further study of OCT technology to monitor or screen for early AD pathology.

Keyphrases

optical coherence tomography
cognitive decline
diabetic retinopathy
mild cognitive impairment
optic nerve
cerebrospinal fluid
electronic health record
big data
machine learning
single cell