Effect of NUDT15 on incidence of neutropenia in children with acute lymphoblastic leukemia.
Jassada BuaboonnamPariwan SripatanatadasakulAjjima TreesuconWaraporn GlomglaoPreeyanun SiraprapapatNattee NarkbunnamNassawee VathanaChayamon TakpraditKamon PhuakpetBunchoo PongtanakulSasima TongsaiPhakatip SinlapamongkolkulKleebsabai SanpakitPublished in: Pediatrics international : official journal of the Japan Pediatric Society (2019)
Patients harboring the CT/TT polymorphism of NUDT15 had a significantly higher incidence of neutropenia during the first 3 months of maintenance, resulting in significantly lower doses of 6-MP.
Keyphrases
- acute lymphoblastic leukemia
- end stage renal disease
- risk factors
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- magnetic resonance imaging
- magnetic resonance
- contrast enhanced
- allogeneic hematopoietic stem cell transplantation
- image quality
- patient reported outcomes