Preparation and SPECT/CT Imaging of 177Lu-Labeled Peptide Nucleic Acid (PNA) Targeting CITED1: Therapeutic Evaluation in Tumor-Bearing Nude Mice.

Jia LiLei ZhangWenbo LiChengming LeiYiyi CaoYing WangZhengjie WangHua Pang

Published in: OncoTargets and therapy (2020)

177Lu-asPNA was developed successfully, showing a high labeling rate and good stability. SPECT/CT imaging demonstrated tumor growth in nude mice, which was effectively inhibited by our probe, thus prolonging survival.

Keyphrases

nucleic acid
high resolution
computed tomography
high fat diet induced
image quality
dual energy
contrast enhanced
pet ct
positron emission tomography
pet imaging
cancer therapy
magnetic resonance
type diabetes
wild type
metabolic syndrome
fluorescence imaging
adipose tissue
photodynamic therapy