METTL3-m 6 A methylase regulates the osteogenic potential of bone marrow mesenchymal stem cells in osteoporotic rats via the Wnt signalling pathway.

Tianli WuHui TangJianghua YangZhihao YaoLong BaiYuping XieQing LiJingang Xiao

Published in: Cell proliferation (2022)

Taken together, the methylation levels and osteogenic potential of OP-BMSCs were decreased in OP-BMSCs. In vitro and in vivo studies, overexpression of Mettl3 could partially rescue the decreased bone formation ability of OP-BMSCs by the canonical Wnt signalling pathway. Therefore, Mettl3 may be a key targeted gene for bone generation and therapy of bone defects in OP patients.

Keyphrases

bone mineral density
cell proliferation
mesenchymal stem cells
end stage renal disease
stem cells
bone marrow
newly diagnosed
ejection fraction
chronic kidney disease
genome wide
postmenopausal women
dna methylation
bone loss
prognostic factors
gene expression
human health