Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination.

Sarah F RosenAllison L SoungWei YangShenjian AiMarlene KanmogneVeronica A DavéMaxim ArtyomovJeffrey A MageeRobyn S Klein

Published in: Genome medicine (2022)

We provide a comprehensive assessment of the role of CXCL16/CXCR6 as an interaction link between microglia and CD8+ T cells that maintains forebrain TRM cells, microglial and astrocyte activation, and ongoing synapse elimination in virally recovered animals. We also show that therapeutic targeting of CXCL16 in mice during recovery may reduce CNS CD8+ TRM cells.

Keyphrases

induced apoptosis
cell cycle arrest
single cell
blood brain barrier
neuropathic pain
endoplasmic reticulum stress
type diabetes
oxidative stress
patient safety
spinal cord
cell migration
lipopolysaccharide induced
cancer therapy
cell proliferation
lps induced