Atmospheric Pressure Drift Tube Ion Mobility-Orbitrap Mass Spectrometry: Initial Performance Characterization.
Joel D KeelorStephen ZambrzyckiAnyin LiBrian H ClowersFacundo M FernándezPublished in: Analytical chemistry (2017)
Atmospheric pressure drift tube ion mobility spectrometry (AP-DTIMS) was coupled with Fourier transform Orbitrap mass spectrometry. The performance capabilities of this versatile new arrangement were demonstrated for different DTIMS ion gating operation modes and Orbitrap mass spectrometer parameters with regard to sensitivity and resolving power. Showcasing the optimized AP-DTIMS-Orbitrap MS system, isobaric peptide and sugar isomers were successfully resolved and the identities of separated species validated by high-energy collision dissociation experiments.
Keyphrases
- mass spectrometry
- high resolution
- liquid chromatography
- gas chromatography
- high resolution mass spectrometry
- high performance liquid chromatography
- capillary electrophoresis
- tandem mass spectrometry
- transcription factor
- particulate matter
- ultra high performance liquid chromatography
- solid phase extraction
- simultaneous determination
- multiple sclerosis
- air pollution
- ms ms