CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation.

Pei-Shan SungShao-Ping YangYu-Chun PengCheng-Pu SunMi-Hwa TaoShie-Liang Hsieh

Published in: Journal of biomedical science (2022)

This study demonstrates that SARS-CoV-2-activated platelets produce EVs to enhance thromboinflammation via CLEC5A and TLR2, and highlight the importance of CLEC5A and TLR2 as therapeutic targets to reduce the risk of ARDS in COVID-19 patients.

Keyphrases

sars cov
toll like receptor
inflammatory response
immune response
respiratory syndrome coronavirus
nuclear factor
oxidative stress
acute respiratory distress syndrome
high glucose
intensive care unit
coronavirus disease