Assessment of exercise-induced changes in von Willebrand factor as a marker of severity of aortic stenosis.
Jo M ZelisFrederik M ZimmermannFroukje P J AndriessenPatrick HouthuizenJop Van de VenJolanda LeuvermanNils P JohnsonNico H J PijlsVolkher ScharnhorstMarcel Van 't VeerPim A L ToninoPublished in: Open heart (2020)
In a cohort of 10 patients with moderate or severe aortic stenosis, we observed no significant change in vWF biomarkers during exercise. Peak CT-ADP during exercise showed a good correlation with peak AV velocity measured with echo. Although CT-ADP is an easy test to perform and could be an alternative for peak AV velocity measured during exercise, our results suggest that it can only detect large changes in shear stress.
Keyphrases
- aortic stenosis
- high intensity
- transcatheter aortic valve replacement
- ejection fraction
- aortic valve replacement
- transcatheter aortic valve implantation
- aortic valve
- left ventricular
- physical activity
- resistance training
- computed tomography
- contrast enhanced
- coronary artery disease
- magnetic resonance
- image quality
- magnetic resonance imaging
- blood flow
- positron emission tomography
- heart failure
- diffusion weighted
- atrial fibrillation