Targeted deep sequencing from multiple sources demonstrates increased NOTCH1 alterations in lung cancer patient plasma.
Yuwei LiaoZhaokui MaYu ZhangDan LiDekang LvZhisheng ChenPeiying LiAisha Ai-DherasiFeng ZhengJichao TianKun ZouYue WangDongxia WangMiguel CordovaHuan ZhouXiuhua LiDan LiuRuofei YuQingzheng ZhangXiaolong ZhangJian ZhangXuehong ZhangXia ZhangYulong LiYanyan ShaoLuyao SongRuimei LiuYichen WangSufiyan SufiyanQuentin LiuGareth I OwenZhiguang LiJun ChenPublished in: Cancer medicine (2019)
Our results confirm previous reports that EGFR mutations are more prevalent than KRAS in Chinese lung cancer patients. NOTCH1 gene alterations are more common than previously reported and reveals a role of NOTCH1 modifications in tumor metastasis. Furthermore, genetic material from malignant pleural effusion cell sediments may be a noninvasive manner to identify CNV and participate in treatment decisions.