Exercise attenuates polyglutamine-mediated neuromuscular degeneration in a mouse model of spinal and bulbar muscular atrophy.

Tomoki HirunagiHideaki NakatsujiKentaro SahashiMikiyasu YamamotoMadoka IidaGenki TohnaiNaohide KondoShinichiro YamadaAyuka MurakamiSeiya NodaHiroaki AdachiGen SobueMasahisa Katsuno

Published in: Journal of cachexia, sarcopenia and muscle (2023)

Our findings suggest the therapeutic potential of exercise-induced effect via AMPK activation in SBMA.

Keyphrases

mouse model
resistance training
high intensity
spinal cord
skeletal muscle
physical activity
body composition
protein kinase