Whole-exome DNA sequencing in childhood anxiety disorders identifies rare de novo damaging coding variants.
Emily OlfsonEli R LebowitzGrace HommelNeha PashankarWendy K SilvermanThomas V FernandezPublished in: Depression and anxiety (2022)
These findings provide a path for identifying risk genes and promising biologic pathways in childhood anxiety disorders by de novo genetic variant detection. Our results suggest the discovery potential of applying this approach in larger anxiety disorder cohorts to advance our understanding of the underlying biology of these common and debilitating conditions.
Keyphrases
- genome wide
- copy number
- dna methylation
- early life
- rheumatoid arthritis
- small molecule
- childhood cancer
- single cell
- circulating tumor
- high throughput
- single molecule
- cell free
- loop mediated isothermal amplification
- young adults
- gene expression
- human health
- real time pcr
- bioinformatics analysis
- climate change
- risk assessment
- transcription factor