The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling.

Ailin LuoZifeng WuShan LiCindy B McReynoldsDi WangHanyu LiuChaoli HuangTeng HeXinying ZhangYuanyuan WangCunming LiuBruce D HammockKenji HashimotoChun Yang

Published in: Journal of translational medicine (2023)

sEH underlies the mechanisms of the comorbidity of chronic pain and depression and that TPPU exerts a beneficial effect on anhedonia behaviors in a pain model via AHR and TSPO signaling.

Keyphrases

chronic pain
pain management
depressive symptoms
sleep quality
pet imaging
computed tomography
spinal cord
physical activity
neuropathic pain