Biomarkers for central nervous system injury in cerebrospinal fluid are elevated in COVID-19 and associated with neurological symptoms and disease severity.
Johan VirhammarAnja NääsDavid FällmarJanet L CunninghamAndrea KlangNicholas J AshtonSven JackmannGabriel WestmanRobert FrithiofKaj BlennowHenrik ZetterbergEva KumlienElham RostamiPublished in: European journal of neurology (2021)
Although limited by the small sample size, our data suggest that levels of NfL protein, GFAp, and total tau in CSF are commonly elevated in patients with COVID-19 with neurological symptoms. This is in contrast to the standard CSF workup where pathological findings are scarce. NfL protein, in particular, is associated with central neurological symptoms and disease severity.