[Cp*IrCl 2 ] 2 -Catalyzed Amidocarbonation of Olefins with Sulfoxonium Ylides toward Functionalized Isoindolin-1-ones.

A [Cp*IrCl 2 ] 2 -catalyzed amidocarbonation of olefins with sulfoxonium ylides has been developed to generate diverse biologically important isoindolin-1-ones in high efficiency under mild reaction conditions. Mechanism studies indicated that this cascade reaction was triggered by amino-iridation of the olefin unit to generate iridacycle, followed by formal migratory insertion with sulfoxonium ylides. This newly developed method features broad substrate scopes and operational simplicity.