A Facile, Efficient, and General Synthetic Method to Amide-Linked Covalent Organic Frameworks.

Amide-linked covalent organic frameworks (amide COFs) possess enormous potentials in practical applications benefiting from their high stability and polyamide structures. However, they suffer from very limited accessibility. Herein, we report a new linkage conversion method to rapidly synthesize crystalline amide COFs through oxidation of imine linkages in their corresponding imine-linked frameworks with KHSO 5 as an oxidant under very mild conditions. This synthetic strategy is general, facile, efficient, and scalable, as demonstrated by the procedure of simply stirring mixtures of imine-linked COFs (seven examples) and KHSO 5 in anhydrous dimethylformamide for several hours to complete the conversions and gram-scale synthesis. The high efficiency of this approach enables facile production of amide COFs from widely available imine-linked COFs, which lays the foundation for exploring practical applications of this unique type of polyamide material.