Prenatal and perinatal factors associated with neonatal neurobehavioral profiles in the ECHO Program.
Marie CamerotaElisabeth C McGowanJudy AschnerAnnemarie StroustrupMargaret R KaragasElisabeth ConradtSheila E CrowellPatricia A BrennanBrian S CarterJennifer CheckLynne M DansereauSheri A DellaGrottaTodd M EversonJennifer B HeldermanJulie A HofheimerJordan R KuiperCynthia M LoncarCarmen J MarsitCharles R NealThomas Michael O'SheaSteven L PastyrnakStephen J SheinkopfLynne M SmithXueying ZhangBarry M LesterPublished in: Pediatric research (2023)
Prior research on predictors of neonatal neurobehavior have included single-cohort studies, which limits generalizability of findings. In a multi-cohort study of preterm and term-born infants, we found six distinct neonatal neurobehavioral profiles, with two profiles being identified as dysregulated. Hypo- and hyper-aroused neurobehavioral profiles had distinct perinatal antecedents. Understanding perinatal factors associated with dysregulated neurobehavior could help promote positive developmental outcomes.