Targeting Akt by SC66 triggers GSK-3β mediated apoptosis in colon cancer therapy.

Yeying LiuYuan HuangJie DingNannan LiuShuang PengJiangang WangFeng WangYingjie Zhang

Published in: Cancer cell international (2019)

Taken together, these data indicated that the novel small molecule AKT inhibitor SC66 shows visible antitumor effects via the AKT/GSK-3β/Bax axis in vitro and in vivo. Our results provide a rational basis for the development of targeting-GSK-3β, which may serve as a potential biomarker and yield meaningful benefits for colon cancer patients in the future.

Keyphrases

signaling pathway
cancer therapy
pi k akt
small molecule
induced apoptosis
cell proliferation
drug delivery
electronic health record
current status
machine learning
big data