The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies.

Daniel J BeardGina HadleyNeal ThurleyDavid W HowellsBrad A SutherlandAlastair M Buchan

Published in: International journal of stroke : official journal of the International Stroke Society (2018)

Low-dose rapamycin treatment may be an effective therapeutic option for stroke. Modest study quality means there is a potential risk of bias. We recommend further high-quality preclinical studies on rapamycin in stroke before progressing to clinical trials.

Keyphrases

cerebral ischemia
low dose
clinical trial
atrial fibrillation
subarachnoid hemorrhage
blood brain barrier
brain injury
stem cells
high dose
cell therapy
climate change
open label
smoking cessation