Plasma Matrix Metalloproteinase Concentrations and Risk of Interstitial Lung Disease in a Prospective Rheumatoid Arthritis Cohort.
Brent A LueddersAustin M WheelerDana P AschermanJoshua F BakerMichael J DuryeeYangyuna YangPunyasha RoulKatherine D WyshamPaul A MonachAndreas ReimoldGail S KerrGary KunkelGrant W CannonJill A PooleGeoffrey M ThieleTed R MikulsBryant R EnglandPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
MMP-7 and MMP-9 were strongly associated with both prevalent and incident ILD in this large, multicenter RA cohort after adjustment for other RA-ILD risk factors. These population-level findings further support a potential pathogenic role for MMPs in RA-ILD and suggest that their measurement could facilitate RA-ILD risk stratification.