Towards a generic method for ion chromatography/mass spectrometry of low-molecular-weight amines in pharmaceutical drug discovery and development.

Zoe LewisBethany A JacksonAlex CramptonAndrew D Ray Stephen W Holman

Published in: Rapid communications in mass spectrometry : RCM (2020)

This study demonstrates the value of IC/MS for analysing low-molecular-weight amines. Good chromatographic separation of mixtures was possible without derivatisation. Ionisation efficiency was greatest using a make-up flow of 0.05% acetic acid in ethanol, and optimisation of ESI source conditions promoted protonated molecule generation for easy determination of molecular weight.

Keyphrases

mass spectrometry
liquid chromatography
drug discovery
ms ms
high performance liquid chromatography
solid phase extraction
tandem mass spectrometry
simultaneous determination
gas chromatography
capillary electrophoresis
high resolution
multiple sclerosis
high speed
ionic liquid
molecularly imprinted