1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma.
Giuseppina D'AlessandroDeborah QuaglioLucia MonacoClotilde LauroFrancesca GhirgaCinzia IngallinaMichela De MartinoSergio FucileAlessandra PorziaMaria Amalia Di CastroFederica BellatoFrancesca MastrottoMattia MoriPaola InfantePaola TuranoStefano SalmasoPaolo CalicetiLucia Di MarcotullioBruno BottaVeronica GhiniCristina LimatolaPublished in: Cell communication and signaling : CCS (2019)
Our results indicate that GlaB inhibits glioma cell growth and exacerbates Warburg effect, increasing lactate production. In addition, the simultaneous blockade of Gli1 and lactate efflux amplifies the anti-tumor effect in vivo, providing new potential therapeutic strategy for this brain tumor.