Sulfotransferase 1C2 Increases Mitochondrial Respiration by Converting Mitochondrial Membrane Cholesterol to Cholesterol Sulfate.

Alexander J KolbPeter CorridonMahbub UllahZechariah J PfaffenbergerWei Min XuSeth WinfreeRuben H SandovalTakeshi HatoFrank A WitzmannRodrigo MohallemJackeline FrancoUma K AryalSimon J AtkinsonDavid P BasileRobert L Bacallao

Published in: Biochemistry (2024)

SULT1C2 increases mitochondrial respiratory capacity by modifying cholesterol, resulting in increased membrane potential and maximal respiratory capacity. This finding uncovers a unique role of SULT1C2 in cellular physiology and extends the role of sulfotransferases in modulating cellular metabolism.

Keyphrases

oxidative stress
low density lipoprotein
heart rate
respiratory tract
resistance training
blood pressure
body composition