TET2 deficiency promotes anxiety and depression-like behaviors by activating NLRP3/IL-1β pathway in microglia of allergic rhinitis mice.
Ziang GaoHao LvYunfei WangYulie XieMengting GuanYu XuPublished in: Molecular medicine (Cambridge, Mass.) (2023)
TET2 deficiency activates the NLRP3/IL-1β pathway of microglia in the ACC, promoting the pathological process of anxiety and depression-like behavior in AR. Metformin could be effective in treating neuroinflammation by regulating microglia via TET2 up-regulation, indicating that metformin is a potential way to treat anxiety and depression-like behaviors in AR.
Keyphrases
- allergic rhinitis
- inflammatory response
- neuropathic pain
- lipopolysaccharide induced
- lps induced
- traumatic brain injury
- signaling pathway
- nlrp inflammasome
- replacement therapy
- spinal cord
- high fat diet induced
- type diabetes
- spinal cord injury
- cognitive impairment
- metabolic syndrome
- insulin resistance
- skeletal muscle
- risk assessment
- cerebral ischemia
- climate change