Targeting sphingosine kinase-1 with the low MW inhibitor SKI-5C suppresses the development of endometriotic lesions in mice.

Jeannette Rudzitis-AuthAnika ChristoffelMichael D MengerMatthias W Laschke

Published in: British journal of pharmacology (2021)

SPHK1/S1P signalling promotes the establishment and progression of endometriotic lesions. The inhibition of this pathway suppresses the development of endometriotic lesions, suggesting SPHK1 as a potential novel target for future endometriosis therapy.

Keyphrases

signaling pathway
stem cells
cancer therapy
type diabetes
tyrosine kinase
risk assessment
metabolic syndrome
climate change
cell therapy