ANG2 Blockade Diminishes Proangiogenic Cerebrovascular Defects Associated With Models of Hereditary Hemorrhagic Telangiectasia.
Xingyan ZhouJenna C PucelAya Nomura-KitabayashiPallavi ChandakkarAdella P GuidrozNikita L JhangianiDuran BaoJia FanHelen M ArthurChristoph UllmerChristian KleinPhilippe MarambaudStryder M MeadowsPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Elevation of ANG2 in the brain vasculature is a shared trait among the mouse models of the common forms of HHT. Inhibition of ANG2 activity can significantly limit or prevent brain arteriovenous malformation formation and blood vessel enlargement in HHT mice. Thus, ANG2-targeted therapies may represent a compelling approach to treat arteriovenous malformations and vascular pathologies related to all forms of HHT.