Perinatal risk factors for neonatal encephalopathy: an unmatched case-control study.

Cally J TannMargaret NakakeetoBarbara A WilleyMargaret SewegabaEmily L WebbIbby OkeEmmanuel Derek MutuuzaDonald PeeblesMargaret MusokeKathryn A HarrisNeil J SebireNigel KleinJennifer J KurinczukAlison M ElliottNicola J Robertson

Published in: Archives of disease in childhood. Fetal and neonatal edition (2017)

Perinatal infection and inflammation are independent risk factors for NE in this low-resource setting, supporting a role in the aetiological pathway of term brain injury. Intrapartum antibiotic administration did not mitigate against adverse outcomes. The importance of intrapartum risk factors in this sub-Saharan African setting is highlighted.

Keyphrases

brain injury
risk factors
subarachnoid hemorrhage
pregnant women
oxidative stress
cerebral ischemia
preterm infants
early onset