Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation.

Andro MontoyaDaniela ElguetaJavier CamposOrnella ChovarPaulina FalcónSoledad MatusIván AlfaroMaría Rosa BonoRodrigo Pacheco

Published in: Journal of neuroinflammation (2019)

These results suggest that DRD3 signalling regulates the dynamic of the acquisition of pro-inflammatory and anti-inflammatory features by astrocytes and microglia, finally favouring microglial activation and promoting neuroinflammation.

Keyphrases

lipopolysaccharide induced
lps induced
inflammatory response
anti inflammatory
traumatic brain injury
neuropathic pain
cognitive impairment
uric acid
spinal cord injury
metabolic syndrome
blood brain barrier