Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine.

Noriyuki ImazuTakehiro TorisuAkihito YokoteJunji UmenoKeisuke KawasakiShin FujiokaYuichi MatsunoTomohiro NagasueShinichiro KawatokoTomohiko MoriyamaTomoki NitahataYushi UchidaSeishi AiharaYoshiaki TaniguchiYoshinao OdaTakanari Kitazono

Published in: Journal of gastroenterology (2024)

ARG2 produces spermidine endogenously in the intestinal epithelium and has a palliative effect on ulcerative colitis. ARG2 and spermidine are potential novel therapeutic targets for UC.

Keyphrases

ulcerative colitis
oxidative stress
palliative care
nitric oxide
human health