Targeted next-generation sequencing has incremental value in the diagnostic work-up of patients with suspect pancreatic masses; a multi-center prospective cross sectional study.

Friso B AchterbergBabs G Sibinga MulderQuisette P JanssenBas Groot KoerkampLieke HolRutger QuispelBert A BonsingAlexander L VahrmeijerCasper H J van EijckDaphne RoosLars E PerkErwin van der HarstPeter-Paul L O CoeneMichail DoukasFrank M M SmedtsMike KliffenMarie-Louise F van VelthuysenValeska TerpstraArantza Farina SarasquetaHans MorreauJ Sven D Mieog

Published in: PloS one (2023)

This study demonstrates the incremental diagnostic value of NGS in patients with an initial inconclusive diagnosis. Integration of NGS results can prevent repeated EUS/FNA, and can also rigorously change the final diagnosis and treatment plan.

Keyphrases

fine needle aspiration
ultrasound guided
copy number
magnetic resonance imaging
gene expression
magnetic resonance
drug delivery
circulating tumor