A Micro Electrochemical Sensor for Multi-Analyte Detection Based on Oxygenated Graphene Modified Screen-Printed Electrode.
Baiqing YuanLiju GanGang LiChunying XuGang LiuPublished in: Nanomaterials (Basel, Switzerland) (2022)
Electrode interfaces with both antibiofouling properties and electrocatalytic activity can promote the practical application of nonenzymatic electrochemical sensors in biological fluids. Compared with graphene, graphene oxide (GO) possesses unique properties such as superior solubility (hydrophilicity) in water, negative charge, and abundant oxygenated groups (oxo functionalities) in the plane and edge sites, which play an essential role in electrocatalysis and functionalization. In this work, a micro electrochemical sensor consisting of GO-modified screen-printed electrode and PDMS micro-cell was designed to achieve multi-analyte detection with excellent selectivity and anti-biofouling properties by electrochemically tuning the oxygen-containing functional species, hydrophilicity/hydrophobicity, and electrical conductivity. In particular, the presented electrodes demonstrated the potential in the analysis of biological samples in which electrodes often suffer from serious biofouling. The interaction of proteins with electrodes as well as uric acid was investigated and discussed.
Keyphrases
- carbon nanotubes
- label free
- uric acid
- gold nanoparticles
- reduced graphene oxide
- solid state
- ionic liquid
- molecularly imprinted
- low cost
- metabolic syndrome
- loop mediated isothermal amplification
- single cell
- risk assessment
- mesenchymal stem cells
- atomic force microscopy
- electron transfer
- solid phase extraction
- simultaneous determination
- structural basis