Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-κB/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling.

Ayman Moawad MahmoudOmnia E HusseinWalaa G HozayenMay Bin-JumahAyman M Mahmoud

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2019)

CA prevented MTX-induced AKI through activation of Nrf2/ARE/HO-1 signaling, and attenuation of ROS-induced activation of NF-κB/NLRP3 inflammasome signaling.

Keyphrases

nlrp inflammasome
oxidative stress
diabetic rats
high glucose
signaling pathway
pi k akt
acute kidney injury
dna damage
lps induced
endothelial cells
nuclear factor
high dose
immune response
toll like receptor