Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked?
Kanwal RehmanMuhammad Sajid Hamid AkashPublished in: Journal of biomedical science (2016)
In this article, we have briefly described that how pro-inflammatory mediators, oxidative stress, transcriptional mediated molecular and metabolic pathways are involved in the pathogenesis of tissues-specific IR. Moreover, based on recent investigations, we have also described that to counterfeit these inflammatory responses is one of the best treatment strategy to prevent the pathogenesis of IR through ameliorating the incidences of inflammatory responses.
Keyphrases
- insulin resistance
- oxidative stress
- gene expression
- adipose tissue
- type diabetes
- metabolic syndrome
- dna damage
- polycystic ovary syndrome
- skeletal muscle
- ischemia reperfusion injury
- induced apoptosis
- heat shock
- combination therapy
- signaling pathway
- single molecule
- high fat diet induced
- endoplasmic reticulum stress
- weight loss