Conduction block in immune-mediated neuropathy: paranodopathy versus axonopathy.

Nidhi GargS B ParkJ HowellsSteve VucicC YiannikasE K MatheyT NguyenYu-Ichi NotoM H BarnettA V KrishnanJ SpiesH BostockJ D PollardM C Kiernan

Published in: European journal of neurology (2019)

The underlying pathologies in CIDP and MMN are distinct. Conduction block in CIDP is associated with paranodal dysfunction which may be antibody-mediated in a subset of patients. In contrast, MMN is characterized by channel dysfunction downstream from the site of block.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
oxidative stress
magnetic resonance
prognostic factors
peritoneal dialysis
patient reported outcomes