Mitochondrial DNA variant spectrum and the association with chronic tic disorders.

Peifang JiangTao ZhuJiajing LiuXiaohan TaoZiru XueYiling TaoHongyu ChenXiaojing ZengWeiyi ZhuQiang ShuLan Yu

Published in: European journal of neurology (2022)

Our data provide evidence of mtDNA variants associated with TDs. The accumulation of the heteroplasmic levels may increase the risk of TDs. Replication studies with larger samples are necessary to understand the pathogenesis of TDs.

Keyphrases

mitochondrial dna
copy number
genome wide
dna methylation
electronic health record
obsessive compulsive disorder
big data
case control