Comprehensive Immunoprofiling of High-Risk Oral Proliferative and Localized Leukoplakia.
Glenn J HannaAlessandro VillaNikhil MistryYonghui JiaCharles T QuinnMadison M TurnerKristen D FeltKathleen PfaffRobert I HaddadRavindra UppaluriScott J RodigSook-Bin WooAnn Marie EgloffF Stephen HodiPublished in: Cancer research communications (2021)
This is the first in-depth profiling effort to immunologically characterize high-risk proliferative leukoplakia as compared with the more common localized leukoplakia. We observed a notable cytotoxic T-cell and Treg signature with relative overexpression of PD-L1 in high-risk proliferative leukoplakia providing a strong preclinical rationale for investigating PD-1/PD-L1 axis blockade in this disease as preventative immunotherapy.