Molecular testing in fine-needle aspiration of thyroid nodules.

Valarie McMurty Sule Canberk Georgios Deftereos

Published in: Diagnostic cytopathology (2022)

Commonly encountered alterations include mutations in RAS, BRAF, TERT promoter, PTEN, and DICER1 as well as fusions of RET, ALK, PAX8-PPARγ, and NTRK. This article provides a summary of these molecular alterations, commercially available molecular assays, and general considerations for thyroid epithelial malignancies and benign thyroid nodules.

Keyphrases

fine needle aspiration
ultrasound guided
cell proliferation
gene expression
insulin resistance
high throughput
wild type
metabolic syndrome
advanced non small cell lung cancer
signaling pathway
single cell
tyrosine kinase