Extracellular histones: a unifying mechanism driving platelet-dependent extracellular vesicle release and thrombus formation in COVID-19.

Alicia S EustesAzaj AhmedJagadish SwamyGokul PatilMelissa JensenKatina M WilsonShibani KudchadkarAbdul WahabUsha PerepuFrancis J MillerSteven R LentzSanjana Dayal

Published in: Journal of thrombosis and haemostasis : JTH (2024)

We conclude that extracellular histones and procoagulant EVs drive the prothrombotic state in COVID-19 and that histone-targeted therapy may prove beneficial.

Keyphrases

coronavirus disease
sars cov
dna methylation
respiratory syndrome coronavirus
gene expression