KDM6A Depletion in Breast Epithelial Cells Leads to Reduced Sensitivity to Anticancer Agents and Increased TGFβ Activity.
Jin-Fen XiaoLey-Fang KuaLing-Wen DingQiao-Yang SunKhine Nyein MyintXiu-Rong ChiaNachiyappan VenkatachalamXinyi LohJason E DuexVanessa NeangSiqin ZhouYing LiHenry YangH Phillip KoefflerDan TheodorescuPublished in: Molecular cancer research : MCR (2022)
Our study provides the preclinical rationale for evaluating KDM6A and TGFβ in breast tumor samples as predictors for response to chemo and immunotherapy, informing personalized therapy based on these findings.