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Design, synthesis and biological potential of heterocyclic benzoxazole scaffolds as promising antimicrobial and anticancer agents.

Saloni KakkarSanjiv KumarBalasubramanian NarasimhanSiong Meng LimKalavathy RamasamyVasudevan ManiSyed Adnan Ali Shah
Published in: Chemistry Central journal (2018)
In vitro antimicrobial results demonstrated that compounds 4, 5, 7 and 16 showed promising antimicrobial potential. The in vitro anticancer activity indicated that compounds 4 and 16 showed promising anticancer activity against human colorectal cancer cell line (HCT 116) when compared to standard drug and these compounds may serve as lead compound for further development of novel antimicrobial and anticancer agents.
Keyphrases
  • staphylococcus aureus
  • endothelial cells
  • human health
  • signaling pathway
  • cell death