Novel biotin-linked amphiphilic calix[4]arene-based supramolecular micelles as doxorubicin carriers for boosted anticancer activity.
Dan DuYu-Dun LiuJun-Bing LanXue-Li HouJia-Dong LiuQing-Hua ShiQing-Wen HuangYun-Sheng XueChao-Guo YanLin AnPublished in: Chemical communications (Cambridge, England) (2023)
Supramolecular carrier-mediated chemotherapy is a highly attractive strategy for targeted drug delivery. In this study, four novel biotin-linked calix[4]arenes BPCA1-BPCA4 have been rationally designed to construct nano-complex with doxorubicin. The in vitro and in vivo assessments reveal that BPCA4-DOX with excellent stability are capable of affording significantly superior anti-tumor activity and lower side effects.