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Blood collection in cell-stabilizing tubes does not impact germline DNA quality for pediatric patients.

Bruce M WollisonEdwin ThaiAimee MckinneyAbigail WardAndrea ClappCatherine ClintonAnwesha NagAaron R ThornerJulie M Gastier-FosterBrian D Crompton
Published in: PloS one (2017)
Our study demonstrates that high-quality genomic studies may be performed from germline DNA obtained in Streck tubes. Therefore, these tubes may be used to simultaneously obtain samples for both liquid biopsy and germline studies in pediatric patients when the volume of blood available for research studies may be limited.
Keyphrases
  • dna repair
  • case control
  • circulating tumor
  • single molecule
  • cell free
  • cell therapy
  • stem cells
  • ionic liquid
  • oxidative stress
  • bone marrow
  • circulating tumor cells