Sex Difference in Capillary Reperfusion After Transient Middle Cerebral Artery Occlusion in Diabetic Mice.
Wenbin ZhuCatherine M DavisElyse M AllenSarah L FellerThierno M BahRobert E ShangrawRuikang K WangNabil J AlkayedPublished in: Stroke (2023)
DM2 impairs capillary perfusion and exacerbates ischemic deep brain injury in male but not female young adult mice. Premenopausal females appear to be protected against DM2-related capillary dysfunction and brain injury.
Keyphrases
- brain injury
- cerebral ischemia
- middle cerebral artery
- subarachnoid hemorrhage
- young adults
- internal carotid artery
- oxidative stress
- postmenopausal women
- acute myocardial infarction
- heart failure
- blood brain barrier
- metabolic syndrome
- type diabetes
- skeletal muscle
- acute ischemic stroke
- childhood cancer
- insulin resistance
- early breast cancer
- drug induced