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Soft strain-insensitive bioelectronics featuring brittle materials.

Yichao ZhaoBo WangJiawei TanHexing YinRuyi HuangJialun ZhuShuyu LinYan ZhouDavid JelinekZhengyang SunKareem YoussefLaurent VoisinAbraham HorrilloKaiji ZhangBenjamin M WuHilary A CollerDaniel C LuQibing PeiSam Emaminejad
Published in: Science (New York, N.Y.) (2022)
Advancing electronics to interact with tissue necessitates meeting material constraints in electrochemical, electrical, and mechanical domains simultaneously. Clinical bioelectrodes with established electrochemical functionalities are rigid and mechanically mismatched with tissue. Whereas conductive materials with tissue-like softness and stretchability are demonstrated, when applied to electrochemically probe tissue, their performance is distorted by strain and corrosion. We devise a layered architectural composite design that couples strain-induced cracked films with a strain-isolated out-of-plane conductive pathway and in-plane nanowire networks to eliminate strain effects on device electrochemical performance. Accordingly, we developed a library of stretchable, highly conductive, and strain-insensitive bioelectrodes featuring clinically established brittle interfacial materials (iridium-oxide, gold, platinum, and carbon). We paired these bioelectrodes with different electrochemical probing methods (amperometry, voltammetry, and potentiometry) and demonstrated strain-insensitive sensing of multiple biomarkers and in vivo neuromodulation.
Keyphrases
  • gold nanoparticles
  • ionic liquid
  • molecularly imprinted
  • molecular dynamics simulations
  • label free
  • oxidative stress
  • quantum dots
  • mass spectrometry
  • carbon nanotubes