Gut Dysbiosis and Increased Intestinal Permeability Drive microRNAs, NLRP-3 Inflammasome and Liver Fibrosis in a Nutritional Model of Non-Alcoholic Steatohepatitis in Adult Male Sprague Dawley Rats.
Larisse LongoJéssica Tonin FerrariPabulo Henrique RampelottoGustavo Hirata DellaviaAmanda PasqualottoClaudia Pinto Marques Souza de OliveiraCarlos Thadeu Schmidt CerskiThemis Reverbel da SilveiraCarolina Uribe-CruzMário Reis Alvares-DA-SilvaPublished in: Clinical and experimental gastroenterology (2020)
This experimental model mimicking human NASH demonstrated gut and liver interaction, with gut microbiota and intestinal permeability changes occurring in parallel with systemic and liver inflammation, miRNAs regulation and liver tissue damage.