High levels of soluble CD25 in COVID-19 severity suggest a divergence between anti-viral and pro-inflammatory T-cell responses.
Min XieJoseph YunisYin YaoJing ShiYang YangPengcheng ZhouKaili LiangYanmin WanAhmed MehdiZhian ChenNaiqi WangShuyun XuMin ZhouMuqing YuKe WangYu TaoYing ZhouXiaochen LiXiansheng LiuXiao YuYunbo WeiZheng LiuJonathan SprentDi YuPublished in: Clinical & translational immunology (2021)
These results suggest that high levels of sCD25 in COVID-19 patients probably result from insufficient anti-viral immunity and indicate an expansion of pro-inflammatory T cells that contribute to disease severity.