Transcriptomics reveals transient and dynamic muscle fibrosis and atrophy differences following spinal cord injury in rats.
Hui Jean KokDrew B FletcherJacob C OsterChristine F ConoverElisabeth R BartonJoshua F YarrowPublished in: Journal of cachexia, sarcopenia and muscle (2024)
Our results substantiate many known pathologic features of SCI-induced wasting in rat skeletal muscle and identify a progressive and dynamic transcriptional landscape within the post-SCI soleus. Future studies are warranted to consider these therapeutic treatment windows when countering SCI muscle pathology.
Keyphrases
- spinal cord injury
- skeletal muscle
- spinal cord
- neuropathic pain
- single cell
- insulin resistance
- multiple sclerosis
- oxidative stress
- diabetic rats
- high glucose
- gene expression
- combination therapy
- adipose tissue
- radiation therapy
- brain injury
- endothelial cells
- rectal cancer
- subarachnoid hemorrhage
- smoking cessation
- heat stress